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OsteoStem™ is a bone repair product designed to improve the structure and function of injured or degenerating bone. Escape will generate OsteoStem™ using a unique manufacturing process whereby ImmuStem™ or MesoStem™ cells are treated with its proprietary osteogenic differentiation factor, OsteoFuse™. When injected into the target bone site, OsteoStem™ is believed to remodel and lay down collagen and other extracellular matrix components normally produced within bone. In preliminary studies, Escape has shown that OsteoStem™ displays a dramatically reduced immunogenicity profile in allorecognition studies. Escape's universal bone repair product allows for the creation of an off-the-shelf extracellular matrix-producing osteogenic cell that can be transplanted into patients of any HLA type, without the need for lifelong immunosuppression. Escape also believes that direct injection of OsteoFuse™ can dramatically enhance osteogenic differentiation of a patient's own mesenchymal stem cells that have already been mobilized to the site of bone injury. OsteoStem™ and OsteoFuse™ to revolutionize the treatment of common bone disorders such as acute fractures and osteoporosis, amongst others.

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