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Using its universal human embryonic stem cell (ESC) line, PluraStem™, Escape is creating an off-the-shelf MSC that can be transplanted into patients of any HLA type without the need for lifelong immunosuppression. Escape's MSC product, MesoStem™, holds the key advantage of stable, long-term suppression of the autoimmune destruction process responsible for type I diabetes progression. Other advantages over unmodified MSC products include more favorable dosing schedules and predictable clinical efficacy. A partial list of the disease indications potentially treatable with Escape's MesoStem™ product is shown below:

Clinical Indications for MesoStem™
Type I diabetes (onset/progression)
Systemic Lupus Erythematosus
Inflammatory Bowel Disease
Rheumatoid Arthritis
Graft-Versus-Host Disease

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